Sooma tDCS

Using mild and non-invasive neuromodulation, Sooma tDCS™ adds a new dimension to the clinical routine for treating patients with major depression.

Sooma depression therapy targets the dorsolateral prefrontal cortex (DLPFC) using a low-intensity (2 mA) direct current. The current induces changes in neuronal excitability in a polarity-dependent manner: positive anodal stimulus increases cortical excitability (depolarization) without triggering action potentials, whereas negative cathodal stimulus decreases excitability (hyperpolarization).


To date, several studies have demonstrated hypoactivity of the left dorsolateral prefrontal cortex (DLPFC) in depressed patients, which may explain why anodal tDCS of the left DLPFC leads to symptom relief in depression patients. (Fitzgerald 2006Grimm 2008)


Overview of transcranial direct current stimulation

  • Non-invasive transcranial direct current stimulation (tDCS) is a safe, effective, and affordable therapeutic option for several psychiatric disorders.
  • tDCS relieves depression symptoms by modulating cortical excitability through a weak current. Specifically, treatment increases the excitability of the left dorsolateral prefrontal cortex (DLPFC), which has been shown to be hypoactive in depressive patients. tDCS does not cause direct action potentials.
  • tDCS is well tolerated, and no serious side effects have been reported.
  • Meta-analyses have found active tDCS treatment to be significantly superior to sham tDCS in depressed patients, and results have been clinically meaningful.
  • tDCS can be used both as a monotherapy or as an adjunct to antidepressant medication and psychotherapy, and the treatment effects may be additive.


Neurobiological studies have demonstrated that tDCS mediates a cascade of events at a cellular and molecular level, including effects on the N-methyl-D-aspartate receptors (Liebetanz 2002Nitsche 2003a). In addition to acute transient membrane potential changes that can last up to one hour, tDCS is associated with longer-lasting synaptic changes (Nitsche 2000Nitsche 2003b).

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